Recombinant Human IL-21 Protein (GMP Grade)
GMP级重组人白介素-21蛋白
目录号： PM111-01
单 价：￥1320
产品详情介绍
白介素-21（interleukin-21，IL-21），属于I类细胞因子，与IL-2、IL-4、IL-15等有较高的同源性，它与IL-7，IL-9共用γ c受体亚单位[1-2]。IL-21由活化的CD4+T细胞分泌，分子结构与IL-15相似，参与调节B细胞增殖，协同IL-15促进骨髓前体细胞增殖和NK细胞增殖、分化和细胞毒活性[3-5]。
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[3] Shi Y, Chen Z, Zhao Z, Yu Y, Fan H, Xu X, Bu X, Gu J. IL-21 Induces an Imbalance of Th17/Treg Cells in Moderate-to-Severe Plaque Psoriasis Patients. Front Immunol. 2019 Aug 7;10:1865.
[4] Nalbant A. IL-17, IL-21, and IL-22 Cytokines of T Helper 17 Cells in Cancer. J Interferon Cytokine Res. 2019 Jan;39(1):56-60.
[5] Sun S, Chen H, Zheng X, Ma C, Yue R. Analysis on the level of IL-6, IL-21, AMH in patients with auto-immunity premature ovarian failure and study of correlation. Exp Ther Med. 2018 Oct;16(4):3395-3398.
