Recombinant Human PDGF-BB Protein (GMP Grade)
GMP级重组人血小板源性生长因子蛋白
目录号： PM119-01
单 价：￥880
产品详情介绍
血小板源性生长因子（Platelet-Derived Growth Factor，PDGF）是一种在多种生理和病理过程中起重要作用的细胞因子。PDGF由两条不同的多肽链组成，通过二硫键连接成二聚体，这使PDGF具有三种形式的二聚体结构，即PDGF-AA，PDGF-BB及PDGF-AB[1-3]。这些二聚体通过与两种类型的受体（PDGFR-α和PDGFR-β）结合来激活细胞内信号传导途径。PDGF-BB主要由血小板、巨噬细胞和肥大细胞产生，尤其在损伤后由血小板分泌。PDGF-BB作为一种有效的促有丝分裂因子，能够促进细胞的增殖和血管生成。另外PDGF-BB在肿瘤的生长发育过程中起着重要的作用，它参与了肿瘤的血管生成，并且是肿瘤诊断和识别的重要生物标志物[4-5]。
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